PAPP-A human, antibody

Cat.# 4P41/4P41cc

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Fertility and pregnancy
  • Cat.#

    4P41/4P41cc

  • MAbs in vitro (Cat.# 4P41cc):

    10E1cc, 10E2cc

  • MAbs in vivo (Cat.# 4P41):

    5H9, 4G11, 3C8, 10H9, 11E4, 7A6, PAPP52

    Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with purified human PAPP-A/proMBP (heterotetrameric PAPP-A, htPAPP-A) complex or purified human atherosclerotic tissue form of PAPP-A (MAb PAPP52).

  • Specificity:

    Human PAPP-A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP-A subunits and proMBP subunits). MAbs 11E4 and 5H9 are specific to proMBP subunit.

  • MAb isotypes:

    IgG1 for MAb PAPP52
    IgG2a for MAbs 4G11, 3C8, 10H9, 7A6
    IgG2b for MAbs 5H9, 11E4, 10E1cc, 10E2cc

  • Applications:

    htPAPP-A and dPAPP-A (PAPP-A dimer) immunoassays and immunoprecipitation.

    Recommended pairs for detection of human htPAPP-A antigen (capture – detection):
    10E2cc – 5H9
    5H9 – 10E2cc
    5H9 – 7A6
    10E1cc – 11E4

    Recommended pairs for detection of total PAPP-A (htPAPP-A and/or dPAPP-A) (capture –detection):
    10E2cc – 10E1cc
    4G11 – 3C8
    4G11 – 10H9
    10E1cc – 7A6

    Please see Cat.# 4PD4 Data Sheet for recommended pairs for specific dPAPP-A antigen detection.

    PAPP-A immunodetection in Western blotting. MAbs 4G11 and 10E1cc recognize htPAPP-A, consisting of PAPP-A subunits and proMBP subunits, in non-reducing conditions.

  • Purification:

    Chromatography on protein A Sepharose.

  • Presentation:

    PBS, pH 7.4, 0.09 % sodium azide (NaN)

  • Storage:

    +4 °C (+2 … +8 °C allowed)

  • Material safety note:

    This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material.

    Product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

  • References:
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PAPP-A human, antibody (MAb: )

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